Laboratories today need faster, more cost effective, and sustainable purification techniques.
Waters SFC Prep 350 System, part of the Waters suite of supercritical fluid chromatography (SFC) sample purification systems, offers the optimal system for the sample amount you need to purify—allowing for easy purification of kilogram scale quantities of one sample.
SFC Prep 350 System
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Operating pressure range |
100 to 320 bar (1450 to 4638 psi) |
|
Liquid CO2 inlet pressure |
55 to 100 bar (797 to 1450 psi) |
|
Liquid CO2 inlet temperature |
5 to 25 °C |
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Cooling of CO2 pump |
Circulating coolant |
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Total flow rate range (CO2 + co-solvent) |
200 to 350 mL/min |
|
Co-solvent percentage range (at maximum total flow of 350 mL/min) |
5% to 55% |
|
Recommended column size |
3 and 5 cm I.D. |
|
Fraction capacity |
5+1 |
* Individual component specifications may allow operation outside the total system defined parameters. The system is designed and tested only for the ranges defined in system specifications.
High pressure pumps are ideal for high pressure, supercritical fluids, and pulseless flow applications.
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Flow rate range for CO2 pump (P-350) |
35 to 350 mL/min |
Liquid pump for adding in co-solvent.
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Flow rate range for co-solvent pump (P-200X) |
20 to 200 mL/min |
The mass flow meter is located on the inlet of the carbon-dioxide pump providing precise flow control.
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Maximum pressure |
100 bar (1450 psi) |
The Injection Module is configured to perform modifier stream injection. An optional configuration change allows mixed stream injection.
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Injection loop |
2 mL standard with 5 mL syringe |
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Wavelength range |
190 to 700 nm |
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UV lamp |
Deuterium |
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Visible lamp |
Tungsten/halogen |
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Flow cell |
Preparative standard |
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Cell material of construction |
Sapphire PEEK, 316 stainless-steel |
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Pathlength |
Preparative 0.5 mm |
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Cell volume |
Preparative 2.0 μL |
The High Pressure Fraction Collection Module utilizes high pressure fraction collection valves to divert flow of desired fractions to the separators. The CO2 gas is vented out from the top of the separators, and the solvent with dissolved material is discharged into the collection bottles.
Six 1 L separators for collecting five fractions and one waste flow stream.
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Voltage |
110 to 220 VAC |
|
Frequency |
50 to 60 Hz |
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Width |
107 cm (42 inches) |
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Height |
135 cm (53 inches) |
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Depth |
92 cm (36 inches) |
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Weight |
195 kg (430 pounds) |
Recommended Use: For recovery of purified products, such as enantiomers, complex synthetic chemicals, and natural products.
One of the largest lab-scale SFC purification systems on the market, Waters SFC Prep 350 System is slated for 100’s gram to kilogram scale compound purification. Ruggedness, simplicity, and productivity are the key principles reflected throughout the instrument design. Classic cyclonic collection is easy-to-use and durable, ideally suited for large compound campaigns. Modified stream injection and stacked injection capability are also featured in the SFC Prep 350 System for high productivity.
The SFC Prep 350 System is ideally suited for large compound campaigns, with features including:
